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M9470092.TXT
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1994-07-02
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Document 0092
DOCN M9470092
TI Characteristics of long-term asymptomatic infection with human
immunodeficiency virus type 1 in men with normal and low CD4+ cell
counts.
DT 9409
AU Keet IP; Krol A; Klein MR; Veugelers P; de Wit J; Roos M; Koot M;
Goudsmit J; Miedema F; Coutinho RA; Municipal Health Service, Department
of Public Health and; Environment, Amsterdam, Netherlands.
SO J Infect Dis. 1994 Jun;169(6):1236-43. Unique Identifier : AIDSLINE
MED/94253580
AB From a cohort study of homosexual men in Amsterdam, 61 human
immunodeficiency virus (HIV)-infected men who had remained asymptomatic
for at least 7 years were identified. In a nested case control study,
these men were compared with 142 men who progressed symptomatic HIV
infection (CDC class IV) within 7 years, regarding laboratory markers,
sexual behavior, psychologic coping, and drug use. Of the 61 long-term
asymptomatic men, 13 had a CD4+ cell count > or = 500/mm3 after 7 years;
in 2 of these 13, the CD4+ cell count had not declined during follow-up.
Independent of CD4+ cell count, long-term asymptomatic HIV-1 infection
was characterized by stable T cell reactivity after stimulation with
monoclonal CD3 antibodies, seropositivity for antibodies to HIV core
proteins, and the absence of hepatitis B markers. No association with
markers of high-risk sex or the recreational use of drugs was found.
Long-term asymptomatic men had a slightly lower score regarding the
coping behavior active problem-solving; no other associations with
coping behaviors were found.
DE Adult Case-Control Studies Cohort Studies Follow-Up Studies
Homosexuality Human HIV
Infections/EPIDEMIOLOGY/*IMMUNOLOGY/PHYSIOPATHOLOGY HIV-1/*IMMUNOLOGY
Immunity, Natural Leukocyte Count Male Reference Values Sex Behavior
Substance Abuse T4 Lymphocytes/CYTOLOGY/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).